Peer-Reviewed Publications

34. Irshad, B., Lu, C., Nederstigt, A. E., Hu, P., Xue, L., Lin-Gereghino, J., Franz, A. H., Harrison, J. S., Lin-Gereghino, G. P. The effect of the bgs13 mutation on the structure of the reporter protein beta-lactoglobulin: Influence on folding and aggregation in Pichia Pastoris, Protein Expr. Purif., 2023, 212, 106355.

33. Parkins, A., Chen, E., Rangel, V. M., Singh, M., Xue, L. Lisi, G. P., Pantouris, G. Ligand-induced conformational changes enable intersubunit communications in D-dopachrome tautomerase, Biophys. J., 2023, 122, 1268-1276.

32. Parkins, A., Das, P., Prahaladan, V., Rangel, V. M., Xue, L., Sankaran, B., Bhandari, V., Pantouris, G. 2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase, Structure, 2023, 31, 1-13.

31. Rangel, V. M., Gu, L., Chen, G., Chen, Q.-H., Xue, L. 5-Substituted 3,3',4'-7-tetramethoxyfalvonoids - A novel class of potent DNA triplex specific binding ligands. Bioorg. Med. Chem. Lett., 2022, 61, 128608.

30. Ranjan, N., Andreasen, K. F., Arora, Y., Xue, L., Arya, D. P. Surface dependent dual recognition of a G-quadruplex DNA with neomycin-intercalator conjugates, Front. Chem., 2020, 8, 1-12.

29. Singh, M., Wang, S., Joo, H., Ye, Z., Christison, K. M., Hekman, R., Vierra, C., Xue, L. Use of neomycin as a structured amino-containing side chain motif for phenanthroline-based G-quadruplex ligands and telomerase inhibitors. Chem. Biol. Drug Des., 2020, 96, 1292-1304.

28. Wang, S., Yang, D., Singh, M., Joo, H., Rangel, V., Tran, A., Phan, E., Xue, L. Thiazole orange - spermine conjugate: a potent human telomerase inhibitor comparable to BRACO-19. Eur. J. Med. Chem., 2019, 175, 20-33.

27. Christison, K. M., Lorenz, R. M., Xue, L., Sparkman, O. D. Exploring the molecular origin of jet fuel thermal oxidative instability through statistical analysis of mass spectral data. Energy Fuels, 2019, 33, 830-836.

26. Wang, S., Singh, M., Ling, M., Li, D., Christison, K. M., Lin-Cereghino, J., Lin-Cereghino, G. P., Xue, L. Synthesis of nucleobase-neomycin conjugates and evaluation of their DNA binding, cytotoxicities, and antibacterial properties. Med. Chem. Res. 2018, 5, 1517-1527.

25. Liu, W., Wang, S., Dotsenko, I., Samoshin, V., Xue, L. Arylsulfanyl goups - suitable side chains for 5-substituted p1,10-henanthroline and nickel complexes as G4 ligands and telomerase inhibitiors. J. Inorg. Biochem. 2017, 173, 12-20.

24. Chahal, S., Wei, P, Moua, P., Park, S. P. J., Kwon, J., Patel, A., Vu, A. T., Catolico, J. A., Tsai, Y., Shaheen, N., Chu, T. T., Tam, V., Khan, Z., Joo, H., Xue, L., Lin-Creghino, J., Tsai, J., Lin-Cereghino, G. P. Structural characterization of the α-mating factor prepro-peptide for secretion of recombinant proteins in Pichia Pastoris, Gene, 2017, 598, 50-62.

23. Xue, L., Ling, M., Wang, S. A reliable method to measure the melting temperatures of DNA oligonucleotide triplexes. J. Under. Chem. Res. 2016, 16, 30-34.

22. Xue, L., Guillen, A., Aggrawal, M., Xue, J. Topological characterization of oxodG containing G-quadruplexes via thermal difference spectra and circular dichroism. J. Under. Chem. Res. 2014, 13, 50-54.

21. Ranjan, N.; Davis, E.; Xue, L. Arya, D. P. Dual recognition of human telomeric G-quadruplex by neomycin-anthraquinone conjugate. Chem. Commun. 2013, 49, 5796-5798.

20. Aggrawal, M.; Joo, H.; Liu, W.; Tsai, J.; Xue, L. 8-Oxo-7,8-dihydrodeoxyadenonsine: the first example of a native DNA lesion that stabilizes human telomeric G-quadruplex DNA. Biochem. Biophys. Res. Commun. 2012, 421, 671-677.

19. Wang, Y.; Yang, D.; Chang, A.; Chan, W. K.; Zhao, B.; Denison, M. S.; Xue, L. Synthesis of a ligand-quencher conjuate for the ligand bindig study of the aryl hydrocarbon receoptor using a FRET assay. Med. Chem. Res. 2012, 21, 711-721.

18. Liu, W.; Minier, M. A.; Franz, A. H.; Curtis, M.; Xue, L. Synthesis of nucleobase-calix[4]arenes via click chemistry and evaluation of their complexation with alkali metal ions and molecular assembly. Supramol. Chem. 2011, 23, 806-818.

17. Xi, H.; Davis, E.; Ranjan, N.; Xue, L.; Hyde-Volpe, D.; Arya, D. P. Thermodynamics of nucleic acid "shape readout" by an aminosugar. Biochemistry 2011, 50, 9088-9113.

16. Minier, M. A.; Shaheen, F.; Lee, A.; Xue, L. Determination of the effect of water-miscible organic solvents on the stability of DNA duplexes via UV thermal denaturation and circular dichroism. J. Under. Chem. Res. 2011, 10, 146-153.

15. Chitranshi, P.; Xue, L. Utilizing G-quadruplex formation to target 8-oxoguanine in telomeric sequences. Bioorg. Med. Chem. Lett. 2011, 21, 6357-6361.

14. Kuman, S.; Xue, L.; Arya, D. P. Neomycin-neomycin conjugate: a carbohydrate scaffold with high affinity for AT rich DNA duplexes. J. Am. Chem. Soc. 2011, 133, 7361-7375.

13. Xue, L; Ranjan, N.; Arya, D. P. Synthesis and spectroscopic studies of aminoglycoside(neomycin)-perylene conjugate binding to human telomeric DNA. Biochemistry 2011, 50, 2838-2849.

12. Xue, L.; Xi, H.; Kumar, S.; Gray, D.; Erick, D.; Paris, H.; Michael, S; Arya, D. P. Probing the recognition surface of a DNA triplex: Binding studies with intercalator-neomycin conjugates. Biochemistry 2010, 49, 5540-5552.

11. Chitranshi, P.; Chen, C.-N.; Jones, P. R.; Faridi, J. S.; Xue, L. Investigation on the interactions of NiCR and NiCR-2H with DNA. Bioinorg. Chem. Appl. 2010, 869569.

10. Curtis, M.; Minier, M. A.; Chitranshi, P.; Sparkmann, O. D.; Jones, P. R.; Xue, L. Direct analysis in real time (DART) mass spectrometry of nucleotides and nucleosides: Elucidation of a novel fragment [C5H5O]+ and its in-source adducts. J. Am. Soc. Mass. Spectrom. 2010, 21, 1371-1381.

9. Liu, W.; Navarro, E.; Franz, A. H., Xue, L. Regioselective bromination of a thymine-acridine conjugate by N-bromosuccinimide. Synth. Commun. 2010, 40, 1192-1201.

8. Xue, L.; Greenberg, M. M. Facile quantification of lesions derived from 2’-deoxyguanosine in DNA. J. Am. Chem. Soc. 2007, 129, 7010-7011.

7. Xue, L.; Greenberg, M. M. Use of fluorescent sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA. Angew. Chem. Intl. Ed., 2007, 46, 561-564.

6. Arya, D. P.; Coffee, Jr. R. L.; Xue, L. From triplex to B-form duplex stabilization: reversal of target selectivity by aminoglycoside dimers. Bioorg. Med. Chem. Lett. 2004, 14, 4643-4646.

5. Arya, D. P.; Xue, L.; Willis, B. Aminoglycoside (neomycin) preference is for A-form nucleic acids, not just RNA: results from a competition dialysis study. J. Am. Chem. Soc. 2003, 125, 10148-10149.

4. Arya, D. P.; Xue, L.; Tennant, P. Combining the best in triplex recognition: synthesis and nucleic acid binding of a BQQ-neomycin conjugate. J. Am. Chem. Soc. 2003, 125, 8070-8071.

3. Arya, D. P.; Micovic, L.; Charles, I.; Coffee, Jr. R. L.; Willis, B.; Xue, L. Neomycin binding to Watson-Hoogsteen (W-H) triplex groove: a model. J. Am. Chem. Soc. 2003, 125, 3733-3744.

2. Charles, I.; Xue, L.; Arya, D. P. Synthesis of aminoglycoside-DNA conjugates. Bioorg. Med. Chem. Lett. 2002, 12, 1259-1262.

1. Xue, L.; Charles, I.; Arya, D. P. Pyrene-neomycin conjugate: dual recognition of a DNA triple helix. Chem. Commun. 2002, 1, 70-71.

Patents:

1. Arya, D. P., Xue, L., Bert, W., Charles, I. Compositions and methods using aminoglycosides to bind DNA and RNA. US60/709,263. 2005

2. Xue, L., Chan, W., Linnet, S., Linnet, T. Rutaecarpine derivatives for activating cyp1a2 in a subject. US20120322816A1. 2013.

3. Linnet, S., Linnet, T., Chan, W., Xue, L. Rutaecarpine derivatives for treating insomnia. US20120322812A1. 2013.

4. Linnet, .T, Linnet, T., Chan, W., Xue, L. Rutaecarpine derivatives for treating caffeine toxicity. US20120322813A1. 2013.

Mailing address: Department of Chemistry, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211 USA